The American White-footed Mouse (Peromyscus leucopus) and the deer mouse (Peromyscus maniculatus), as well as other common species of mouse-like rodents around the world, also sometimes live in houses. These, however, are in other genera.

Cats, wild dogs, foxes, birds of prey, snakes and even certain kinds of arthropods have been known to prey heavily upon mice. Nevertheless, because of its remarkable adaptability to almost any environment, the mouse is one of the most successful mammalian genera living on Earth today.

Mice can at times be harmful rodents, damaging and eating crops, causing structural damages and spreading diseases through their parasites and feces. In North America, breathing dust that has come in contact with mouse excrements has been linked to hantavirus, which may lead to Hantavirus Pulmonary Syndrome (HPS).